{"id":2187,"date":"2015-12-10T16:47:47","date_gmt":"2015-12-10T21:47:47","guid":{"rendered":"http:\/\/drupal.test\/projects\/projet-nord-americain-de-mutagenese-conditionnelle-de-la-souris-analyse-fonctionnelle-haut-rendement\/"},"modified":"2022-08-18T13:17:18","modified_gmt":"2022-08-18T17:17:18","slug":"projet-nord-americain-de-mutagenese-conditionnelle-de-la-souris-analyse-fonctionnelle-haut-rendement","status":"publish","type":"project","link":"https:\/\/dev.genomecanada.ca\/fr\/project\/projet-nord-americain-de-mutagenese-conditionnelle-de-la-souris-analyse-fonctionnelle-haut-rendement\/","title":{"rendered":"Projet nord-am\u00e9ricain de mutagen\u00e8se conditionnelle de la souris : analyse fonctionnelle \u00e0 haut rendement de mammif\u00e8res pour la d\u00e9couverte de nouveaux facteurs d\u00e9terminants des maladies humaines"},"content":{"rendered":"

Les souris knockout sont des organismes mod\u00e8les dans lesquels des g\u00e8nes sp\u00e9cifiques ont \u00e9t\u00e9 d\u00e9sactiv\u00e9s. Ces organismes g\u00e9n\u00e9tiquement modifi\u00e9s permettent de comprendre le r\u00f4le des modifications g\u00e9n\u00e9tiques dans l\u2019\u00e9volution des maladies humaines. L\u2019International Knock-out Mouse Project est une initiative internationale qui vise \u00e0 produire des mutations de neutralisation dans chacun des g\u00e8nes du g\u00e9nome de la souris, ce qu\u2019on consid\u00e8re comme l\u2019\u00e9tape suivante la plus importante apr\u00e8s le projet du g\u00e9nome humain.<\/p>\n

M. Geoff Hicks, biologiste sp\u00e9cialiste du cancer \u00e0 chercheur principal au Manitoba Institute of Cell Biology, institut conjoint de CancerCare Manitoba et de l\u2019Universit\u00e9 du Manitoba, et Mme <\/sub><\/sup>Janet Rossant, biologiste du d\u00e9veloppement \u00e0 l\u2019H\u00f4pital pour enfants malades, dirigent le Projet nord-am\u00e9ricain de mutagen\u00e8se conditionnelle de la souris : analyse fonctionnelle \u00e0 haut rendement de mammif\u00e8res pour la d\u00e9couverte de nouveaux facteurs d\u00e9terminants des maladies humaines. Le projet, dont la contribution \u00e0 l\u2019International Knock-out Mouse<\/p>\n

Project sera consid\u00e9rable, vise \u00e0 identifier et \u00e0 caract\u00e9riser les fonctions des g\u00e8nes des souris. L\u2019\u00e9quipe dirig\u00e9e par M. Hicks et Mme Rossant d\u00e9terminera des lign\u00e9es de cellules dans lesquelles tous les g\u00e8nes de souris soumis \u00e0 l\u2019\u00e9tude sont neutralis\u00e9s et mettra ces lign\u00e9es \u00e0 la disposition de la communaut\u00e9 scientifique et biotechnologique. De plus, l\u2019\u00e9quipe cr\u00e9era des applications bas\u00e9es sur les cellules pr\u00e9caract\u00e9ris\u00e9es et des applications informatiques concernant les g\u00e8nes cibles associ\u00e9s \u00e0 la maladie et cr\u00e9era un centre de diffusion pour que les projets canadiens de recherche biom\u00e9dicale, publics ou priv\u00e9s, puissent plus facilement profiter de cette base de connaissances.<\/p>\n

Les lign\u00e9es de cellules g\u00e9n\u00e9tiquement modifi\u00e9es, mises au point par l\u2019\u00e9quipe du projet, permettront aux chercheurs d\u2019\u00e9lucider le r\u00f4le exact des modifications g\u00e9n\u00e9tiques dans le d\u00e9veloppement de certaines maladies humaines. Ces r\u00e9sultats devraient acc\u00e9l\u00e9rer le rythme auquel les nouvelles d\u00e9couvertes m\u00e9dicales sont transform\u00e9es en interventions th\u00e9rapeutiques possibles, puis utilis\u00e9es dans la prestation des soins de sant\u00e9.<\/p>\n

(En anglais seulement.)<\/p>\n

Integrated GE3<\/sup>LS Research:<\/strong> Socio-economic impacts of institutional\/business practices and intellectual property structures
\nGE3<\/sup>LS Project Leaders:<\/strong> Edna Einsiedel, University of Calgary and Tania Bubela, University of Alberta
\nSummary<\/u>
\nThe GE3<\/sup>LS component of this research, effectively a case study of the NorCOMM project as it develops, will allow insights into the ongoing debate about the effects of institutional\/business practices and intellectual property structures on access to research tools; rates of innovation; knowledge and innovation flows; rights of developers and innovators; and access to products and processes of innovation.<\/p>\n

To address the impacts of the NorCOMM resource, the GE3<\/sup>LS activities have three principal aims: <\/p>\n

    \n
  1. To explore costs and benefits of different network structures, funding models and intellectual property practices on the development of resources for genomics research and impacts on knowledge flows in the domain of mouse genomics and human genetic disease research.<\/li>\n
  2. To use multi-method approaches to track knowledge and innovation flows including new computational methods to visualize the knowledge domain of mouse genomics<\/li>\n
  3. To use bibliometric and scientometric methods to objectively assess and prioritize gene targets for Canada\u2019s public and private research sectors. <\/li>\n<\/ol>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Les souris knockout sont des organismes mod\u00e8les dans lesquels des g\u00e8nes sp\u00e9cifiques ont \u00e9t\u00e9 d\u00e9sactiv\u00e9s. Ces organismes g\u00e9n\u00e9tiquement modifi\u00e9s permettent de comprendre le r\u00f4le des modifications g\u00e9n\u00e9tiques dans l\u2019\u00e9volution des maladies humaines. L\u2019International Knock-out Mouse Project est une initiative internationale qui vise \u00e0 produire des mutations de neutralisation dans chacun des g\u00e8nes du g\u00e9nome de […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[238],"project-sector":[],"genome_centres":[107],"class_list":["post-2187","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-concours-iii","genome_centres-genome-prairie-fr"],"acf":[],"yoast_head":"\nProjet nord-am\u00e9ricain de mutagen\u00e8se conditionnelle de la souris : analyse fonctionnelle \u00e0 haut rendement de mammif\u00e8res pour la d\u00e9couverte de nouveaux facteurs d\u00e9terminants des maladies humaines - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Projet nord-am\u00e9ricain de mutagen\u00e8se conditionnelle de la souris : analyse fonctionnelle \u00e0 haut rendement de mammif\u00e8res pour la d\u00e9couverte de nouveaux facteurs d\u00e9terminants des maladies humaines - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"Les souris knockout sont des organismes mod\u00e8les dans lesquels des g\u00e8nes sp\u00e9cifiques ont \u00e9t\u00e9 d\u00e9sactiv\u00e9s. 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