On sait que la g\u00e9n\u00e9tique joue un r\u00f4le consid\u00e9rable dans de nombreux troubles neurologiques du d\u00e9veloppement et troubles du comportement, mais dans la plupart des cas, on ne conna\u00eet pas encore l\u2019anomalie mol\u00e9culaire responsable. Il n\u2019existe donc pas de tests pour d\u00e9celer et diagnostiquer pr\u00e9cocement ces troubles et on poss\u00e8de peu d\u2019information sur leur fondement biologique. Un nombre croissant de troubles neurologiques et de troubles du comportement sont toutefois caus\u00e9s par des modifications de l\u2019architecture de sites sp\u00e9cifiques le long de l\u2019ADN des chromosomes du g\u00e9nome humain. L\u2019information obtenue gr\u00e2ce au s\u00e9quen\u00e7age du g\u00e9nome humain a en outre fait ressortir l\u2019importance de ces modifications chromosomiques, car on sait maintenant qu\u2019elles portent des \u00ab signatures mol\u00e9culaires \u00bb qui facilitent les r\u00e9organisations du mat\u00e9riel g\u00e9nomique.<\/p>\n
De plus, il a \u00e9t\u00e9 montr\u00e9 que la structure du g\u00e9nome et le nombre de copies des g\u00e8nes localis\u00e9s \u00e0 des sites pr\u00e9cis du g\u00e9nome varient entre les individus et les esp\u00e8ces, ce qui semble jouer ensuite un r\u00f4le important dans l\u2019\u00e9volution. Les sites, qui comportent le pourcentage \u00e9tonnant de 5 % (150 millions de bases chimiques) du contenu du g\u00e9nome humain et ces signatures mol\u00e9culaires, qu\u2019on appelle duplications segmentaires ou r\u00e9plicons, n\u2019ont pas encore \u00e9t\u00e9 caract\u00e9ris\u00e9s exactement ou int\u00e9gralement par les projets \u00e0 grande \u00e9chelle de s\u00e9quen\u00e7age de l\u2019ADN.<\/p>\n
Des groupes de recherche scientifique de l\u2019Universit\u00e9 de Toronto, de l\u2019Universit\u00e9 de la Colombie\u00adBritannique, de SeeDNA Biotech, de la Fundacio Parc de Recera Ciomedica de Barcelone, de l\u2019Universit\u00e9 Pomeu Fabra, de MedPlant Genetics (Espagne), et de CAGTCitogen (Espagne) comptent \u00e9galement au nombre des chercheurs principaux. Pour de plus amples renseignements visitez : www.tcag.ca<\/p>\n","protected":false},"excerpt":{"rendered":"
On sait que la g\u00e9n\u00e9tique joue un r\u00f4le consid\u00e9rable dans de nombreux troubles neurologiques du d\u00e9veloppement et troubles du comportement, mais dans la plupart des cas, on ne conna\u00eet pas encore l\u2019anomalie mol\u00e9culaire responsable. Il n\u2019existe donc pas de tests pour d\u00e9celer et diagnostiquer pr\u00e9cocement ces troubles et on poss\u00e8de peu d\u2019information sur leur fondement […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[250],"project-sector":[],"genome_centres":[108],"class_list":["post-2016","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-projets-mixtes-de-genoma-espana-et-de-genome-canada-dans-les-domaines-de-la-sante-humaine-des-vegetaux-et-de-laquaculture-r-d-e","genome_centres-ontario-genomics-fr"],"acf":[],"yoast_head":"\n