{"id":10674,"date":"2016-07-12T15:39:20","date_gmt":"2016-07-12T15:39:20","guid":{"rendered":"http:\/\/drupal.test\/projects\/developpement-preclinique-de-medicaments-visant-prevenir-les-hemorragies-intracerebrales\/"},"modified":"2022-07-26T12:47:56","modified_gmt":"2022-07-26T16:47:56","slug":"developpement-preclinique-de-medicaments-visant-prevenir-les-hemorragies-intracerebrales","status":"publish","type":"project","link":"https:\/\/dev.genomecanada.ca\/fr\/project\/developpement-preclinique-de-medicaments-visant-prevenir-les-hemorragies-intracerebrales\/","title":{"rendered":"D\u00e9veloppement pr\u00e9clinique de m\u00e9dicaments visant \u00e0 pr\u00e9venir les h\u00e9morragies intrac\u00e9r\u00e9brales"},"content":{"rendered":"<p>L\u2019h\u00e9morragie intrac\u00e9r\u00e9brale (HIC) est une forme d\u2019h\u00e9morragie c\u00e9r\u00e9brale qui cause 10\u00a0% de tous les accidents vasculaires c\u00e9r\u00e9braux (AVC). Elle survient chez environ 90\u00a0000\u00a0personnes par ann\u00e9e en Am\u00e9rique du Nord, dont plus de la moiti\u00e9 en meurt ou devient handicap\u00e9e. Entre un \u00bc et 44\u00a0% des survivants ont des HIC r\u00e9currentes. Le fardeau \u00e9conomique annuel de l\u2019HIC est \u00e9valu\u00e9 \u00e0 300\u00a0millions de dollars au Canada et \u00e0 6\u00a0milliards de dollars aux \u00c9tats-Unis. Outre le traitement de l\u2019hypertension, l\u2019une des causes de l\u2019HIC, il n\u2019y a actuellement aucun moyen de pr\u00e9venir l\u2019HIC r\u00e9currente.<\/p>\n<p>D<sup>r<\/sup> Xiao-Yan Wen, directeur du Zebrafish Centre for Advanced Drug Discovery (ZCADD), et son \u00e9quipe \u00e0 l\u2019H\u00f4pital St. Michael\u2019s, ont utilis\u00e9 des outils de recherche g\u00e9nomiques pour cibler plusieurs m\u00e9dicaments d\u00e9j\u00e0 approuv\u00e9s par la Food and Drug Administration (FDA) des \u00c9tats-Unis et susceptibles de pr\u00e9venir l\u2019HIC dans des mod\u00e8les de poissons z\u00e8bres. Dans ce projet, Edge Therapeutics s\u2019associe au D<sup>r<\/sup> Wen pour effectuer des \u00e9tudes pr\u00e9cliniques des mol\u00e9cules anti-HIC les plus puissantes, appel\u00e9es EZF-0100, pour traiter l\u2019HIC et les microh\u00e9morragies c\u00e9r\u00e9brales (MHC). Selon les r\u00e9sultats de ces \u00e9tudes, Edge pourrait explorer l\u2019utilisation de sa technologie Precisa<sup>MD<\/sup> pour mettre au point au moyen d\u2019administrer le m\u00e9dicament en mode de lib\u00e9ration lente et peut aussi synth\u00e9tiser et analyser des analogues de l\u2019EZF-0100 pour d\u00e9terminer le meilleur candidat-m\u00e9dicament en vue d\u2019un d\u00e9veloppement pr\u00e9clinique et d\u2019une \u00e9tude clinique au Canada et aux \u00c9tats-Unis.<\/p>\n<p>Le projet renforcera le r\u00f4le de chef de file de ZCADD dans le d\u00e9veloppement de m\u00e9dicaments, attirera de nouveaux partenariats et de nouveaux investissements et assurera des revenus au Centre. Il formera aussi les chercheurs et les entrepreneurs de la prochaine g\u00e9n\u00e9ration et cr\u00e9era de nouveaux emplois pour les Canadiennes et les Canadiens.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019h\u00e9morragie intrac\u00e9r\u00e9brale (HIC) est une forme d\u2019h\u00e9morragie c\u00e9r\u00e9brale qui cause 10\u00a0% de tous les accidents vasculaires c\u00e9r\u00e9braux (AVC). Elle survient chez environ 90\u00a0000\u00a0personnes par ann\u00e9e en Am\u00e9rique du Nord, dont plus de la moiti\u00e9 en meurt ou devient handicap\u00e9e. Entre un \u00bc et 44\u00a0% des survivants ont des HIC r\u00e9currentes. Le fardeau \u00e9conomique annuel de [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[92],"genome-competitions":[210],"project-sector":[],"genome_centres":[108],"class_list":["post-10674","project","type-project","status-publish","hentry","project-categories-translation-fr","genome-competitions-programme-de-partenariats-pour-les-applications-de-la-genomique","genome_centres-ontario-genomics-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>D\u00e9veloppement pr\u00e9clinique de m\u00e9dicaments visant \u00e0 pr\u00e9venir les h\u00e9morragies intrac\u00e9r\u00e9brales - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"D\u00e9veloppement pr\u00e9clinique de m\u00e9dicaments visant \u00e0 pr\u00e9venir les h\u00e9morragies intrac\u00e9r\u00e9brales - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"L\u2019h\u00e9morragie intrac\u00e9r\u00e9brale (HIC) est une forme d\u2019h\u00e9morragie c\u00e9r\u00e9brale qui cause 10\u00a0% de tous les accidents vasculaires c\u00e9r\u00e9braux (AVC). 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