{"id":10660,"date":"2016-06-21T15:27:21","date_gmt":"2016-06-21T15:27:21","guid":{"rendered":"http:\/\/drupal.test\/projects\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\/"},"modified":"2022-07-26T12:42:51","modified_gmt":"2022-07-26T16:42:51","slug":"sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0","status":"publish","type":"project","link":"https:\/\/dev.genomecanada.ca\/fr\/project\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\/","title":{"rendered":"SIRP\u03b1Fc : Transformation de la recherche en g\u00e9nomique en une nouvelle immunoth\u00e9rapie contre le cancer"},"content":{"rendered":"<p>Presque toutes (96\u00a0%) les personnes de 65 et plus qui re\u00e7oivent un diagnostic de leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb (LMA) en meurent dans les cinq ans qui suivent, tout comme les deux tiers des patients moins \u00e2g\u00e9s. On s\u2019attend \u00e0 une augmentation de l\u2019incidence de cette maladie au cours des prochaines ann\u00e9es parce qu\u2019elle touche principalement les personnes \u00e2g\u00e9es et que la population vieillit. Les r\u00e9gimes de chimioth\u00e9rapie pour la LMA sont demeur\u00e9s essentiellement les m\u00eames depuis les ann\u00e9es\u00a01970. Les traitements standards permettent \u00e0 de nombreux patients de conna\u00eetre une r\u00e9mission, mais dans la plupart des cas, le cancer r\u00e9cidivera; et apr\u00e8s la r\u00e9cidive, les deux tiers des patients meurent dans les trois ans.<\/p>\n<p>Le taux \u00e9lev\u00e9 de r\u00e9cidive de la LMA s\u2019explique en partie par le fait que la chimioth\u00e9rapie type ne tue pas les cellules souches de la leuc\u00e9mie, mais les laisse cro\u00eetre et atteindre la maturit\u00e9 en de nouvelles cellules de leuc\u00e9mie. Les cellules souches de la leuc\u00e9mie expriment des taux \u00e9lev\u00e9s d\u2019une prot\u00e9ine appel\u00e9e CD47. Cette prot\u00e9ine envoie un signal \u00ab\u00a0ne mange pas \u00e7a\u00a0\u00bb qui emp\u00eache les globules blancs du syst\u00e8me immunitaire, appel\u00e9s macrophages, d\u2019entourer et \u00ab\u00a0de manger\u00a0\u00bb les cellules canc\u00e9reuses.<\/p>\n<p>Gr\u00e2ce \u00e0 un financement accord\u00e9 pr\u00e9c\u00e9demment par G\u00e9nome Canada et Trillium Therapeutics Inc. (TTI), une soci\u00e9t\u00e9 publique de biotechnologie de Toronto, au Canada, M<sup>me\u00a0<\/sup>Jean Wang, Ph.\u00a0D., et son \u00e9quipe du Princess Margaret Cancer Centre, du R\u00e9seau universitaire de la sant\u00e9, et M<sup>me<\/sup>\u00a0Jayne Danska, Ph.\u00a0D., et son \u00e9quipe \u00e0 l\u2019H\u00f4pital pour enfants malades (SickKids) ont mis au point le SIRP\u03b1Fc, un nouveau produit th\u00e9rapeutique qui bloque le signal \u00ab\u00a0ne mange pas \u00e7a\u00a0\u00bb, ce qui permet au syst\u00e8me immunitaire d\u2019attaquer les cellules souches de la leuc\u00e9mie. TTI proc\u00e8de aux \u00e9tudes pr\u00e9cliniques officielles et effectuera les essais cliniques visant \u00e0 d\u00e9montrer l\u2019efficacit\u00e9 et l\u2019innocuit\u00e9 de SIRP\u03b1Fc. La collaboration de M<sup>mes<\/sup>\u00a0Wang \u00a0et Danska et de TTI aidera \u00e0 r\u00e9aliser le potentiel commercial de cette d\u00e9couverte prometteuse.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Presque toutes (96\u00a0%) les personnes de 65 et plus qui re\u00e7oivent un diagnostic de leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb (LMA) en meurent dans les cinq ans qui suivent, tout comme les deux tiers des patients moins \u00e2g\u00e9s. On s\u2019attend \u00e0 une augmentation de l\u2019incidence de cette maladie au cours des prochaines ann\u00e9es parce qu\u2019elle touche principalement les [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[92],"genome-competitions":[210],"project-sector":[],"genome_centres":[108],"class_list":["post-10660","project","type-project","status-publish","hentry","project-categories-translation-fr","genome-competitions-programme-de-partenariats-pour-les-applications-de-la-genomique","genome_centres-ontario-genomics-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>SIRP\u03b1Fc : Transformation de la recherche en g\u00e9nomique en une nouvelle immunoth\u00e9rapie contre le cancer - GenomeCanada<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SIRP\u03b1Fc : Transformation de la recherche en g\u00e9nomique en une nouvelle immunoth\u00e9rapie contre le cancer - GenomeCanada\" \/>\n<meta property=\"og:description\" content=\"Presque toutes (96\u00a0%) les personnes de 65 et plus qui re\u00e7oivent un diagnostic de leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb (LMA) en meurent dans les cinq ans qui suivent, tout comme les deux tiers des patients moins \u00e2g\u00e9s. On s\u2019attend \u00e0 une augmentation de l\u2019incidence de cette maladie au cours des prochaines ann\u00e9es parce qu\u2019elle touche principalement les [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dev.genomecanada.ca\/fr\/project\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\/\" \/>\n<meta property=\"og:site_name\" content=\"GenomeCanada\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-26T16:42:51+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/project\\\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\\\/\",\"url\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/project\\\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\\\/\",\"name\":\"SIRP\u03b1Fc : Transformation de la recherche en g\u00e9nomique en une nouvelle immunoth\u00e9rapie contre le cancer - GenomeCanada\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/#website\"},\"datePublished\":\"2016-06-21T15:27:21+00:00\",\"dateModified\":\"2022-07-26T16:42:51+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/project\\\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/project\\\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/project\\\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"SIRP\u03b1Fc : Transformation de la recherche en g\u00e9nomique en une nouvelle immunoth\u00e9rapie contre le cancer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/\",\"name\":\"GenomeCanada\",\"description\":\"Harnessing the transformative power of genomics\",\"publisher\":{\"@id\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/#organization\",\"name\":\"GenomeCanada\",\"url\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/dev.genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"contentUrl\":\"https:\\\/\\\/dev.genomecanada.ca\\\/wp-content\\\/uploads\\\/2021\\\/07\\\/genome-canada_stacked.svg\",\"width\":285,\"height\":180,\"caption\":\"GenomeCanada\"},\"image\":{\"@id\":\"https:\\\/\\\/dev.genomecanada.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"SIRP\u03b1Fc : Transformation de la recherche en g\u00e9nomique en une nouvelle immunoth\u00e9rapie contre le cancer - GenomeCanada","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"fr_FR","og_type":"article","og_title":"SIRP\u03b1Fc : Transformation de la recherche en g\u00e9nomique en une nouvelle immunoth\u00e9rapie contre le cancer - GenomeCanada","og_description":"Presque toutes (96\u00a0%) les personnes de 65 et plus qui re\u00e7oivent un diagnostic de leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb (LMA) en meurent dans les cinq ans qui suivent, tout comme les deux tiers des patients moins \u00e2g\u00e9s. On s\u2019attend \u00e0 une augmentation de l\u2019incidence de cette maladie au cours des prochaines ann\u00e9es parce qu\u2019elle touche principalement les [&hellip;]","og_url":"https:\/\/dev.genomecanada.ca\/fr\/project\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\/","og_site_name":"GenomeCanada","article_modified_time":"2022-07-26T16:42:51+00:00","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/dev.genomecanada.ca\/fr\/project\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\/","url":"https:\/\/dev.genomecanada.ca\/fr\/project\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\/","name":"SIRP\u03b1Fc : Transformation de la recherche en g\u00e9nomique en une nouvelle immunoth\u00e9rapie contre le cancer - GenomeCanada","isPartOf":{"@id":"https:\/\/dev.genomecanada.ca\/fr\/#website"},"datePublished":"2016-06-21T15:27:21+00:00","dateModified":"2022-07-26T16:42:51+00:00","breadcrumb":{"@id":"https:\/\/dev.genomecanada.ca\/fr\/project\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dev.genomecanada.ca\/fr\/project\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/dev.genomecanada.ca\/fr\/project\/sirpafc-transformation-de-la-recherche-en-genomique-en-une-nouvelle-immunotherapie-contre-le-0\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/dev.genomecanada.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"SIRP\u03b1Fc : Transformation de la recherche en g\u00e9nomique en une nouvelle immunoth\u00e9rapie contre le cancer"}]},{"@type":"WebSite","@id":"https:\/\/dev.genomecanada.ca\/fr\/#website","url":"https:\/\/dev.genomecanada.ca\/fr\/","name":"GenomeCanada","description":"Harnessing the transformative power of genomics","publisher":{"@id":"https:\/\/dev.genomecanada.ca\/fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dev.genomecanada.ca\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/dev.genomecanada.ca\/fr\/#organization","name":"GenomeCanada","url":"https:\/\/dev.genomecanada.ca\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/dev.genomecanada.ca\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/dev.genomecanada.ca\/wp-content\/uploads\/2021\/07\/genome-canada_stacked.svg","contentUrl":"https:\/\/dev.genomecanada.ca\/wp-content\/uploads\/2021\/07\/genome-canada_stacked.svg","width":285,"height":180,"caption":"GenomeCanada"},"image":{"@id":"https:\/\/dev.genomecanada.ca\/fr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/dev.genomecanada.ca\/fr\/wp-json\/wp\/v2\/project\/10660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.genomecanada.ca\/fr\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/dev.genomecanada.ca\/fr\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":0,"href":"https:\/\/dev.genomecanada.ca\/fr\/wp-json\/wp\/v2\/project\/10660\/revisions"}],"wp:attachment":[{"href":"https:\/\/dev.genomecanada.ca\/fr\/wp-json\/wp\/v2\/media?parent=10660"}],"wp:term":[{"taxonomy":"project-categories","embeddable":true,"href":"https:\/\/dev.genomecanada.ca\/fr\/wp-json\/wp\/v2\/project-categories?post=10660"},{"taxonomy":"genome-competitions","embeddable":true,"href":"https:\/\/dev.genomecanada.ca\/fr\/wp-json\/wp\/v2\/genome-competitions?post=10660"},{"taxonomy":"project-sector","embeddable":true,"href":"https:\/\/dev.genomecanada.ca\/fr\/wp-json\/wp\/v2\/project-sector?post=10660"},{"taxonomy":"genome_centres","embeddable":true,"href":"https:\/\/dev.genomecanada.ca\/fr\/wp-json\/wp\/v2\/genome_centres?post=10660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}