Les cellules souches ont le pouvoir extraordinaire d\u2019aider \u00e0 traiter certaines des maladies les plus intraitables \u2014 par exemple le diab\u00e8te, l\u2019arthrite, l\u2019accident vasculaire c\u00e9r\u00e9bral, et les troubles neurologiques comme le Parkinson et l\u2019Alzheimer. Nous ne sommes pas encore capables d\u2019utiliser des cellules souches pour traiter ces maladies pa rce que nous devons d\u2019abord en savoir beaucoup plus sur ces cellules. Pour exploiter pleinement et enti\u00e8rement le potentiel des cellules souches, il faut comprendre les facteurs g\u00e9n\u00e9tiques qui font des cellules souches ce qu\u2019elles sont et comment se pr\u00e9cisent les diff\u00e9rents types de cellules et de tissus de l\u2019organisme.<\/p>\n
Nous d\u00e9terminons quels g\u00e8nes sont actifs dans les cellules souches \u00e0 l\u2019aide de nouvelles m\u00e9thodes de d\u00e9tection et d\u2019analyse appel\u00e9es puces d\u2019ADN, d\u2019essais en s\u00e9rie de l\u2019expression des g\u00e8nes et d\u2019\u00e9tudes des prot\u00e9ines (prot\u00e9omique). Nous avons \u00e9tudi\u00e9 les cellules souches d\u2019embryons d\u2019humains et de souris, de m\u00eame que du muscle, du cerveau et de la moelle \u00e9pini\u00e8re chez des adultes. Les cellules ont \u00e9t\u00e9 pr\u00e9lev\u00e9es sur des souris de laboratoire et des \u00e9chantillons de biopsies faites sur des humains et conserv\u00e9es sous forme de cultures cellulaires en laboratoire pour les utiliser dans nos exp\u00e9riences. Nous avons effectu\u00e9 1 400 exp\u00e9riences au moyen de puces d\u2019ADN et 11 essais en s\u00e9rie de l\u2019expression des g\u00e8nes; nous avons fait des analyses prot\u00e9iques de presque 140 \u00e9chantillons de prot\u00e9ines. Nous avons cr\u00e9\u00e9 une base de donn\u00e9es appel\u00e9e StemBase, qui comprend de nouvelles m\u00e9thodes d\u2019affichage graphique et d\u2019analyse. Cette base de donn\u00e9es est mise \u00e0 la disposition publique des chercheurs sur les cellules souches de partout dans le monde. Globalement, 25 chercheurs de toutes les r\u00e9gions canadiennes ont particip\u00e9 \u00e0 notre projet de recherche. <\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
Les cellules souches ont le pouvoir extraordinaire d\u2019aider \u00e0 traiter certaines des maladies les plus intraitables \u2014 par exemple le diab\u00e8te, l\u2019arthrite, l\u2019accident vasculaire c\u00e9r\u00e9bral, et les troubles neurologiques comme le Parkinson et l\u2019Alzheimer. Nous ne sommes pas encore capables d\u2019utiliser des cellules souches pour traiter ces maladies pa rce que nous devons d\u2019abord en […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"project-categories":[93],"genome-competitions":[237],"project-sector":[],"genome_centres":[108],"class_list":["post-10530","project","type-project","status-publish","hentry","project-categories-large-scale-science-fr","genome-competitions-concours-ii","genome_centres-ontario-genomics-fr"],"acf":[],"yoast_head":"\n